Development and descent of the testis in relation to cryptorchidism.

نویسندگان

  • Helena E Virtanen
  • Dina Cortes
  • Ewa Rajpert-De Meyts
  • E Martin Ritzén
  • Agneta Nordenskjöld
  • Niels E Skakkebaek
  • Jorma Toppari
چکیده

UNLABELLED The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. CONCLUSION Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

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عنوان ژورنال:
  • Acta paediatrica

دوره 96 5  شماره 

صفحات  -

تاریخ انتشار 2007